Abstract

EVALUATION OF ANTIULCER ACTIVITY OF ETHANOL EXTRACT OF AGANOSMA CYMOSA BY PYLORUS LIGATION METHOD

Keerthi Birudaraju* and Gokarigari Srikanth

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Abstract

Objective: The current study set out to determine whether an ethanolic extract of Aganosma Cymosa (EEAC) had an anti-ulcer properties. Materials and Methods: Rats were given 150 and 300 mg/kg of EEAC, and the effects on acute toxicity and pyloric ligation tests were examined. Results: Up to 2000 mg/kg, p.o. body weight in rats, EEAC was determined to be safe and to cause no mortality or behavioural abnormalities. The current study's findings demonstrated that Aganosma cymosa has a clear pro healing effect. The ethanolic extract of Aganosma cymosa plant leaves significantly increased the percentage of peptic ulcer closure in the pylorus ligation ulcer model. The increased collagen synthesis caused by aganosmacyamosa may be the cause of the epithelization. Conclusion: EEAC may be helpful in the conventional treatment of ulcers since it showed anti-ulcer action, This could be brought on by the existence of saponins and flavonoids.

Keywords: Pyloric ligation, Ulcer, Aganosma cymosa, Ranitidine, epithelisation.