Abstract

IN-VITRO EVALUATION OF ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF MALVASTRUM CORAMANDELIANUM

V. Suresh*, S. K. Senthil Kumar, S. Logeshwari, P. Manochithra, M. S. Mohammed Muaaz, S. Naveenkumar and T. Nevethini

Abstract

There are several factors that may induce ulcers in human beings such as stress, chronic use of anti-inflammatory drugs, etc. Though in most cases, the etiology of ulcer is unknown, it has generally accepted that it is the result of an imbalance between aggressive factors and maintenance of the mucosal integrity through the endogenous defense mechanism. Thus, the search for a safe anti-ulcer drug that optimizes these properties is continuing, and part of the search is the evaluation of medicinal plants for gastro protective properties. The Malvastrum coromandelianum has used in folk medicine for the treatment of inflammation and gastrointestinal diseases. In this study, we assessed for anti-ulcer activities with aqueous extract and in-vitro method as the acid neutralizing capacity, effects on artificial gastric acid neutralization and the neutralization duration capacity of a prepared preparation on artificial stomach acid, the extract significantly reduced ANC at a concentration of 1000 mg as compared with standard Aluminium hydroxide Magnesium hydroxide (500mg). While the effect on artificial gastric acid neutralization is nearly compare to the standard drug and the titration method of Fordtran’s model for the determination of ANC value.

Keywords: Malvastrum coromandelianum, Anti-Ulcer, Aluminium hydroxide, Magnesium hydroxide.