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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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ICV : 90.8

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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

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Abstract

PYRAZOLE DERIVATIVES AS AN ENOYL ACYL CARRIER PROTEIN REDUCTASE (INHA) INHIBITORS WITH PROMISING ANTITUBERCULAR ACTIVITY

Kinjal Nayee*, Beenkumar Prajapati and Haribhai Rabari

Abstract

Tuberculosis is an infectious disease caused by bacillus Mycobacterium tuberculosis (MTB). New drugs with different mechanisms of action against tuberculosis must be discovered and developed in response to the rising prevalence of multidrug-resistant MTB. Several pyrazole derivatives have been synthesized and tested for anti-tubercular activity in past years. Enoyl acyl carrier protein reductase (InhA), is a clinically proven target for tuberculosis treatment. This review outlines the effectiveness of pyrazole derivatives as an InhA inhibitors and their antitubercular potential.

Keywords: Tuberculosis, Pyrazole, Enoyl Acyl Carrier Protein Reductase (InhA), Antitubercular Activity.

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