Abstract

ANALGESIC ACTIVITY OF LEAF LATEX OF ALOE PERCRASSA TODARO AND ALOE CAMPERI SCHWEINFURTH IN MICE

Gereziher Geremedhin Sibhat* and Gomathi Periasamy

Abstract

Aloe Aloe percrassa and Aloe camperi are among the indigenous aloe species growing in Tigray region, Northern Ethiopia. They are traditionally used for the management of pain, malaria, wounds, gastro Intestinal and dermatological problems. Leaf latex of Aloe percrassa and Aloe camperi were collected by putting the leaves concentrically around a plate. Acute toxicity study of the latex of both plants was also determined. Tail immersion method was used to evaluate invivo analgesic potential of the leaf latex in Swiss albino mice model. The results showed that the leaf latexes of both plants were found to have significant analgesic activity at oral dose of 200 & 400 mg/kg when compared to latency period of negative control group. The results obtained from the present study support the traditional use of the leaf latex of Aloe percrassa and Aloe camperi in painful conditions.

Keywords: Aloe percrassa, Aloe camperi, Analgesic activity, Invivo, Latex.