Abstract

AN EFFICIENT ONE-POT SYNTHESIS OF BENZOXAZOLE DERIVATIVES CATALYZED BYNICKEL SULPHATE

Shaik Lakshman*, N. Krishnarao, V. Narasingrao, K. Vidhya and B. V. Durgarao

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Abstract

In this study, we report the design, synthesis, structural characterization, and biological evaluation of novel benzoxazole from 2-aminophenol and substituted aldehydes in the presence of catalytic amount of nickel supported silica at room temperature.as potential therapeutic agents. A one-pot, two component cyclocondensation reaction under synthesized conventional methods. All compounds were characterized using1HNMR, 13CNMR, and mass spectrometry. Additionally, desired compound demonstrated notable antibacterial activity, outperforming the standard Streptomycin and Ketonozole and certain derivatives displayed moderate to high antimicrobial efficacy against key bacterial and fungal strains these findings suggest that benzoxazole derivatives hold significant promise for further development as therapeutic agents.

Keywords: Benzoxazole, One-pot two-component synthesis, 2-Aminophenol, Substituted aromatic aldehydes, NiSO4 2H2O, antibacterial activity.