Abstract

EFFECT OF SHWETA PARPATI AND NAGARADI KASHAYA IN THE MANAGEMENT OF UROLITHIASIS

Dr. Sreevidya P. R.* and Dr. Sunil John Thykkattil MD (Ay)

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Abstract

Background: Urolithiasis is the formation of urinary calculi at any level of the urinary tract. Urinary calculi are worldwide in distribution but are particularly common in some geographic locations such as in part of United States, South Africa, India and Southeast Asia. The problem of stone formation is considered as a medical challenge due to multifactorial aetiology involving intrinsic factors (e.g., age, sex, heredity) and extrinsic factors (e.g., geography, climate, diet, mineral composition and water intake). Current treatment modalities like ESWL & PCNL are costly and recurrence chance is also more. In Ayurveda classics, Acharyas have given a detailed description regarding urinary stones which is known as Mutrashmari. Many formulations with Ashmari Bhedhaka property mentioned in ayurvedic literatures are cost effective, devoid of complications and provide wide scope for the successful treatment of Mutrashmari. Aim: To evaluate the efficacy of internal administration of Nagaradi Kashaya and Shweta Parpati in the management of Urolithiasis. Settings and Design: The study was an interventional pre-post study with sample size of 21. Participants were selected according to inclusion and exclusion criteria defined in study methodology. A detailed history of participant along with urinalysis and abdominal / Pelvic USG was used for diagnosis. Materials and Methods: Participant were administered with the trial drug for 45 Days. Follow up of the patients were performed every 15 days. Results of urinalysis and abdominal / Pelvic USG reports on 46th day, along with clinical assessment of Subjective parameters (Pain, Renal Angle Tenderness, Burning Micturition and Dysuria), and Objective parameters (Haematuria, Epithelial cells and Pus cells in urine) were reviewed and summarized to confirm the effectiveness of the trial drug. Result: Outcome variables were size and number of stones, changes in urinalysis, score of signs and symptoms which was analysed before and after the treatment. Further statistical analysis was performed using Wilcoxon signed-rank test and Paired t-Test as applicable. Number of stones and the size of stones among the participants shown a remarkable change with p ≤ 0.001. The change in signs and symptoms like Pain, Burning Micturition, Dysuria and Renal Angle Tenderness also shown a p < 0.001 on statistical analysis. Statistical analysis results of Haematuria (p = 0.01), Epithelial cells (p = 0.001), Pus cells (p < 0.001) indicate a remarkable change with a significant p < 0.05. Conclusion: The study result shows that the combination trial drug of Nagaradi kashaya and Shweta parpati is effective in management of Urolithiasis.

Keywords: Mutrashmari; Urolithiasis; Shweta Parpati; Nagaradi Kashaya; Kidney stone; Urinary Calculus.