OCULAR PRESERVATIVES: AN OVERVIEW
*Tasneem Ara1, Sanjay Sharma2, Shabeer Ahmad Bhat1, Abdul Samieh Deva3, Barina Deva3, Nitish Bhatia4
Abstract
The patient suffering from ocular diseases usually are subjected to a
variety of topical medications As per the USFDA requirement all
topical ophthalmic preparations in multidose containers should be able
to resist most microbial contamination so preservatives are added to
multidose medications bottles to resist /inhibit the microbial
contamination. Preservatives are included in multiple-dose eye
solutions for maintaining the product sterility during use. Preservatives
are not included in unit-dose package. The use of preservatives is
prohibited in ophthalmic products that are used in eye surgery because,
if sufficient concentration of the preservative is contacted
with the corneal endothelium, the cells can become damaged causing clouding of the cornea
and possible loss of vision. So these products should be packaged in sterile unit dosage
containers. The most common organism is Pseudomonas aeruginosa that grow in the cornea
and cause loss of vision.Preservatives used have been linked to various unwanted ocular
surface side effects like ocular toxicity, inflammation, allergy, disruption of the tear film .so
keeping this in view, the manufacturers of ocular medications have developed new
preservative systems in order to limit these toxic side effects .this article gives a deep insight
of the various preservatives which are used in various ophthalmic preparations.
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