Abstract

FORMULATION AND ASSESSMENT FOR DIABETIC FOOT ULCER FROM MUSA PARADISIACA (L.) EXTRACT

Anand P.*, Sona Joshy, Abhirami K. U., Sasikala V. V., Vibina Paulson and Ashish Paul

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Abstract

Diabetic foot ulcer is a common skin disease on the foot due to neuropathic and vascular complications shown in type 2 Diabetic mellitus patient. Appropriate foot care is vitally important in the treatment of foot lesion. Musa paradisiaca L is a popular Indian medicinal plant belong to the Musaceae family, exhibits various pharmacological properties and can be utilized in the treatment of diabetic foot ulcers. The study aimed to formulate and evaluate a powder formulation of Musa paradisiaca L using the Soxhlation extraction method, targeting its application in the wound healing treatment of diabetic foot ulcers (DFU). Musa leaves extract was prepared and collected through Soxhlet extraction and the methanolic extract was analyzed using the GC-MS method to identify its chemical constituents. Various formulations were prepared using the crude extract and appropriate excipients and the selected formulations were subsequently evaluated. The powder formulation was tested for physical parameters, which shows excellent consistency and flow property. Significant wound healing properties were obtained from in vitro assays analysis such as, antioxidant, anti-inflammatory and antimicrobial activity. Based on the background of all studies conducted, the powder formulation has proven to be effective for diabetic foot ulcers (DFU). Besides its efficacy, this formulation is also easily applicable and economically beneficial for patients.

Keywords: DFU, Musa Paradisiaca L, antioxidant, anti-inflammatory and antimicrobial activity.