Abstract

PTSA CATALYZED SYNTHESIS OF SCHIFF’S BASE VIA 1, 3, 4- THIADIAZOL-2-AMINE

K. Rajeswari, Ch. Jyothi and N. Krishnarao*

Abstract

An effective technique for creating a new Schiff base(5a-5f), (E)-5- styryl-1, 3, 4-thiadiazol-2-amine, with P-substituted aromatic aldehyde in the presence P-toluenesulphonic acid at room temperature ethanol as a solvent and the cinnamicacid and with thiosemicarbaide can be converted into the intermediate molecule (E)-5-styryl-1, 3, 4- thiadiazol-2-amine(3) in the presence of acid medium . Advanced spectroscopic data (1HNMR, 13CNMR, and LCMS) were used to analyze all of the freshly synthesized derivatives. Additionally, elemental analysis was used to determine the structural determination of the compounds. All of the newly discovered compounds were then examined for their antibacterial properties.

Keywords: (E)-5-styryl-1,3,4-thiadiazol-2-amine,substituted aromatic aldehydes, P-toluene sulfonic acid, Schiff bases, bioevluation.