Abstract

“PRONIOSOMES AS NEXT-GENERATION DRUG CARRIERS: A REVIEW OF CURRENT INNOVATIONS”

Makrand Ekatpure, Gaurav Yadav*, Iram Naaz Shaikh, Archit Desai, Uzma Khan and Ayush Kate

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Abstract

The development of innovative drug delivery systems has revolutionized medication administration, improving targeted delivery, stability, and controlled release. Among these, proniosomes have emerged as a promising vesicular drug delivery system. Proniosomes are dry formulations composed of non-ionic surfactants, cholesterol, and carriers, which upon hydration form niosomes. These systems enhance drug bioavailability, reduce toxicity, and provide sustained release, making them superior to conventional dosage forms. This review explores the structure, components, types, preparation methods, characterization techniques, advantages, limitations, and clinical applications of proniosomes. Proniosomes offer enhanced stability, efficient drug encapsulation, and targeted delivery for various therapeutic applications, including anti-cancer, anti-infective, and transdermal drug delivery. Their potential in pharmaceutical research highlights their role as a next-generation drug carrier with significant advantages over traditional systems.

Keywords: Proniosomes, Vesicular Drug Delivery, Controlled Release, Targeted Drug Delivery, Non-Ionic Surfactants, Transdermal Drug Delivery, Niosomes, Pharmaceutical Carriers.