Abstract

QUALITATIVE PHYTOCHEMICAL SCREENING AND IN–VITRO EVALUATION OF ANTI-HELMINTHIC ACTIVITY USING HYDROALCOHOLIC EXTRACT AND AQUEOUS EXTRACT OF ACALYPHA INDICA LEAVES

P. Sathya Sowmya*, R. Pavan Sai, O. Ravi Teja, G. Chandra Sekhar

Abstract

The hydroalcholic extract and aqueous extract of Acalypha indica is used as antihelminths. An antihelmintic (also called antihelmintic) is a drug or substance used to expel or destroy parasitic worms (helminths) from the body, typically by either stunning or killing them without causing significant harm to the host. These drugs are commonly used in both human and veterinary medicine to treat infections caused by roundworms, tapeworms, and flukes.The present study screening of bioactive constituents from Acalypha indica utilizing an array of hydroalcholic extract and aqueous extract alongside an evaluation of their anthelmintic efficacy. Qualitative and the presence of different bioactive components such as alkaloids, flavonoids, tannins, saponins, and glycosides, indicative of the plant’s diverse metabolic collections. The anthelmintic potential of the extracts was rigorously assessed employing Pheretima posthuma as a biological model, with results demonstrating both extracts at different concentrations of extract, along with compare standard antihelmintic drug praziquantel as evidenced by significant paralysis and mortality rates. This investigation provides a foundation for the isolation and structural elucidation of the bioactive molecules, potentially advancing novel therapeutic agents.

Keywords: Acalypha indica, Phytochemical investigation, Antihelmintic activity, hydroalcholic extract, Pheritima posthuma.