Abstract

AN OVERVIEW ON THE OPHTHALMIC FORMULATION FOR INSITU GEL FORMATION

*Pavithra B., Deepshika P., Divya M., Nirmala S., Thilagavathi R. and Sankar C.

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Abstract

In situ gelling systems in ophthalmic preparations represent a significant advancement In the context of ocular drug delivery, this method yields superior therapeutic outcomes as well as patient compliance. These innovative formulations undergo sol-to-gel transitions upon instillation into the eye, triggered by physiological stimulation such as pH, thermal profile, or Ionic concentration. This change allows the medication to remain in the eye for a longer period, release slowly over time, and reduce the amount absorbed into the rest of the body, thereby overcoming the drawbacks of traditional eye drops This review provides a detailed analysis of the polymers used in these systems, focusing on their ability to respond to stimuli and their role in improving drug delivery. It covers various types of in-situ formulations, such as pH-sensitive, temperature-responsive, and ionactivated systems. The article also highlights the importance of assessing these gels through rheological, cell-based studies, and preclinical animal studies to ensure toxicity profile, efficacy, patient acceptance. By examining these factors, the review emphasizes the potential of In situ gelling systems to transform the treatment of eye diseases and enhance.

Keywords: in-situ gels, Polymers, Types of in-situ gels, Rheology.