Abstract

DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE DETERMINATION OF MONTELUKAST SODIUM IN PHARMACEUTICAL FORMULATIONS

N. Vani*, Dr. P. Vasanthkumar, Dr. P.R. Logeshkumar, R. Greeshma, V. Manjula, C. Nagamani, S. Naveen, S. Prathap, R. Umadevi and P. Yuvaraju

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Abstract

Worldwide over 300 million people are affected by asthma which is a chronic inflammatory disease. Allergic rhinitis and the presence of proinflammatory cells and mediators in the circulation of patients qualifying asthma as a systemic disease are the common Associators. Persistent asthma therapy, inhaled corticosteroids can’t suppress all components of airway inflammation and fails to penetrate in small airways, warrant the quest for effective systemic anti-asthma therapies. These Project describes the most important controlled studies of Montelukast Sodium which is a Leukotriene receptor antagonist (LTRA) used for maintenance treatment of asthma and to relive symptoms of seasonal allergies. It comes as a tablet, a chewable tablet and granules to take by mouth which is usually taken once a day with or without food. Montelukast Sodium which is systemically active drug with a targeted dual mechanism of action acting both as a bronchodilator and anti-inflammatory for aged patients. It is a Well tolerated drug for both as monotherapy are in combination with inhaled corticosteroids.

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