Abstract

DEVELOPMENT OF PSOCURIN- AN INNOVATIVE FORMULATION FOR MANAGING PSORIASIS SYMPTOMS

Farzeen Nazeem Shaikh*, Anam Farid Baig and Dr. Gauri Vahalkar

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Abstract

A natural herbal formulation was developed to manage psoriasis symptoms. In combination with bioactive ingredients like pomegranate peel powder, mulethi (licorice) powder, neem powder, curcumin extract, silymarin extract, and honey, known for their antiinflammatory, antioxidant, antimicrobial, and skin-repairing properties, this unique mixture targets psoriasis triggers such as immune dysfunction, oxidative stress, and microbial imbalances. The proinflammatory cytokines like TNF-α and IL-6 were inhibited by the formulation through pathways such as NF-κB, COX-2, and MAPK, which also helps in reducing inflammation and oxidative damage. Curcumin and silymarin extracts assist in cellular repair and skin regeneration, while pomegranate peel, Mulethi, and neem powders help in lowering inflammatory markers and relieve skin irritation. The natural antimicrobial properties of neem and honey help in controlling microbial load, enhancing the product's effectiveness. Proximate analysis, phytochemical screening, and microbial evaluation confirmed the formulation's safety, quality, and stability. With a low-fat content and a mildly acidic pH, the formulation is acceptable for irritable psoriatic lesions. Shelf-life studies gave an idea for the product's stability for up to four weeks under refrigerated conditions. By utilizing ecofriendly ingredients, the formulation provides a sustainable and holistic alternative to conventional treatments. It effectively bridges dermatological care with environmentally responsible practices, making it an ideal solution for individuals seeking long-term psoriasis symptom management. Future research will focus on extended stability studies and clinical evaluations to further validate its therapeutic potential.

Keywords: Psoriasis, herbal formulation, skin regeneration, Silymarin extract, Curcumin extract.