Abstract

A PROSPECTIVE OBSERVATIONAL STUDY ON PRESCRIPTION PATTERN AND RATIONAL USE OF PROKINETICS AND PROBIOTICS IN TERTIARY CARE HOSPITAL

*Md. Abed Alam, *E. Sindhuja, *E. Rohith Goud, *G. Pravalika and *Dr. D. Venkata Ramana

Abstract

Aim: To identify prescribing patterns and rational drug use of prokinetics and probiotics in tertiary care hospital, Secunderabad. Objectives: To assess the effects of prokinetic and probiotic prescription practices. To examine how probiotics and prokinetics are used to treat various illnesses. They evaluate the drawbacks of taking probiotics and prokinetics. To assess probiotics and prokinetics' effectiveness and safety for a range of illnesses. To ascertain probiotics and prokinetics efficacy. Methods: 200 cases were gathered for the study, which was supported out over six months at the KIMS Sunshine Hospital in Secunderabad. The data was obtained from patient case sheets from several departments where the patients received surgery. Results: A total of 200 subjects were recruited for the research, for the study, 116 men and 84 women were presumably recruited. When considering gender as a variable, we can state that men (58%) and women (42%), respectively. The age range with the highest percentage (23.5%) was between 46 and 60, while the lowest percentage (12%) was between 18 and 30. Prokinetics were given more frequently than probiotics, based on the drug's categorization. The majority of prokinetics and probiotic prescriptions were made in surgical gastroenterology and liver transplantation (i.e., 73 (36.5%)), followed by general medicine (i.e., 67 (33.5%). The probiotic and prokinetic treatments had greater OD frequencies (49.5%), with HS (bedtime) frequencies displaying the lowest frequency ( Prokinetics andprobiotic prescription patterns are greater for monotherapy (81.9%) and 90.7%, re spectively, and are followed by triple treatment, which has a lesser range (3%), (0%), respectively. Conclusion In the present clinical study, it is concluded that the outcomes of Prokinetics and probiotics often highlight the potential for health benefit s, improving symptoms and individual responses. The most often prescribed prokinetic medication in the study was Levosulpiride ( metoclopramide (11%), Prucalopride ( and Domperidone ( The most often prescribed probiotic medication in th is study was Caps VSL#3 (60%), Tab. Sporlac (11%), Cap.Providac (28%). Although prokinetics and probiotics have a high range of efficacy but accompanied by several adverse effects on the longer duration of administration of drugs. This study concludes that Prucalopride is a safer prokinetic drug in ameliorating digestive motility disorders and related symptoms and is widely prescribed. It is suggested that rather than other prokinetic drugs prucalopride is effective in achieving a sustained benefit in the m ajority of patients. And cap vsl is a probiotic drug that is more often prescribed which is mainly used to maintain a healthy digestive tract and found to be associated with several AEs. It is suggested that regular prescription monitoring should be done t o encourage rational use of drugs.

Keywords: Prescription pattern, Prokinetics, Probiotics, Functional dyspepsia, Gastroparesis, Gut microbiota, Bifidobacterium strains, Prucalopride, CAP VSL#3.