Abstract

MICROSPONGE-BASED TOPICAL DELIVERY SYSTEMS: A VERSATILE APPROACH FOR ENHANCED THERAPIES

Mamatha G. T., Hithesh P.*, Mahalakshmi A. S. and Spoorthy R.

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Abstract

The microsponge delivery system is an advanced polymeric technology designed to enhance the effectiveness of topical drug delivery. It consists of highly cross linked, porous microspheres capable of entrapping active ingredients and releasing them gradually into the skin over an extended period. This sustained release mechanism offers several benefits, including prolonged drug action, reduced skin irritation, enhanced patient tolerance, and improved thermal, physical, and chemical stability of the formulation. Microsponges are manufactured using different techniques, such as suspension polymerization in a liquid-liquid system or emulsion-based methods. These techniques create porous structures that allow the controlled release of active ingredients. Due to their unique properties, microsponges are incorporated into various dermatological and cosmetic formulations, including creams, powders, gels, and lotions. Additionally, they can encapsulate a wide range of pharmaceutical and cosmetic agents, such as anti-inflammatory drugs, skin lightening agents, sunscreens, and anti-aging compounds. One of the key advantages of microsponges is their ability to improve drug penetration into the skin while minimizing irritation, making them highly beneficial for sensitive skin applications. Their sustained-release capability also ensures a prolonged therapeutic effect, reducing the need for frequent application. This review focuses on the technology of microsponges, covering their synthesis, advantages, characterization, evaluation, and drug release mechanisms in topical drug delivery systems.

Keywords: Microsponge, Microsphere, Topical delivery, Versatile approach, Quasi emulsion solvent diffusion