Abstract

TARGETED DRUG DELIVERY IN GASTROESOPHAGEAL REFLUX DISEASE: THE ROLE OF MUCOADHESIVE AND LIPOSOME SYSTEMS

Sneha N. R.*, Krishna K. R. and Parthiban S.

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Abstract

Gastroesophageal reflux disease (GERD) is a chronic condition characterized by the reflux of gastric contents into the esophagus, leading to symptoms such as heartburn and regurgitation. Conventional treatments, including proton pump inhibitors (PPIs), often provide temporary relief but may not address the root causes of the disease and can have adverse side effects with long-term use. In response, novel drug delivery systems, such as mucoadhesive and liposomal systems, have emerged as promising alternatives for more effective treatment. Mucoadhesive drug delivery systems improve the localized treatment of GERD by prolonging the residence time of drugs at the site of action in the gastrointestinal tract. These systems adhere to the mucosal surface, providing sustained drug release and improving the therapeutic efficacy. Similarly, liposomal drug delivery systems enhance the bioavailability and stability of drugs by encapsulating them in lipid-based vesicles. Liposomes also offer targeted drug delivery, reducing systemic side effects and ensuring controlled release at the site of need. This review discusses the potential of mucoadhesive and liposomal drug delivery systems in managing GERD. It examines their mechanisms, benefits, and challenges, while also highlighting recent research and developments in this area. These innovative drug delivery approaches have the potential to offer safer, more effective, and patient-friendly treatment options for GERD, improving both local and systemic therapeutic outcomes.

Keywords: Targeted drug delivery, Gastroesophageal reflux disease, Mucoadhesive, Liposome.