Abstract

REVIEW ARTICLE ON CHANDIPURA VESICULOVIRUS AND IT'S CURRENT SCENARIO IN INDIA

Rakibe Vaishali, Vidhate Shruti, Wankhede Komal*, Yelmate Shreyash and Yuvraj Chavan

Abstract

Chandipura virus was first found in year 1965, after which it shown various outbreak in year 1980, 1995, 2003, 2004, 2010, 2014, but it catches the global attention in year 2003-04 as it's shown its major spread in various states of India mainly Gujrat, Maharashtra and Andhrapradesh. In 2003-2004 Central India faced an major outbreak witnessing case fatality rates ranging from 56-75 per cent in Rajasthan, Madhya Pradesh and Gujarat with major encephalitic symptoms. These virus belongs to the Rhabdoviridae family, and shows similarities with Rabbis virus. The main vector for this Virus is Flies, mosquito etc, Phlebotomine sandflies are implicated as the vectors due to their predominance in endemic areas, repeated virus isolations and their ability to transmit the virus by transovarial and venereal routes. The major symptoms observed are Fever, Headaches, Fatigue, Body and muscle aches, Vomiting, Convulsions. The diagnosis is done with IFA and RT- PCR.[56] Due to unavailability of any approved vaccine for the Chandipura Vesiculovirus, the treatment is generally based on preventive measures. Two candidate vaccines have been developed: 1) A recombinant vaccine and a killed vaccine. 2) Sirnas targeting the P and M proteins. 3) Glycoprotein based vaccine and they are now awaiting clinical trials.

Keywords: Chandipura Vesiculovirus (CHPV), lFA, RT PCR, Acute syphilis syndrome.