Abstract

A REVIEW ON BENZIMIDAZOLE AND ITS BIOLOGICAL ACTIVITY

Neha Shyam Bora* and Dr. M.S.Bhosale

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Abstract

This review paper provides a comprehensive overview of the biological and pharmacological properties of benzimidazole and its compounds, emphasizing their significance in medicinal chemistry. Benzimidazole, a heterocyclic compound containing an imidazole ring, forms the backbone of various natural products and pharmaceuticals, including histidine and histamine. The paper highlights the historical context of benzimidazole discovery and its composition of the structure. It categorizes the diverse pharmacological profiles of benzimidazole derivatives, which exhibit a range of biological activity, including antiviral, anticancer, anti-inflammatory, analgesic, and antibacterial qualities. The evaluation of multiple synthesized benzimidazole compounds demonstrates their effectiveness against various pathogens and conditions, including drug-resistant bacterial strains and tuberculosis. The paper also discusses the mechanisms underlying these activities, including COX-2 inhibition and antioxidant effects, while stressing the potential for new therapeutic agents derived from benzimidazole scaffolds. Overall, the findings emphasize how crucial benzimidazole is as a versatile pharmacophore in the development of novel drugs targeting a wide array of diseases.

Keywords: Benzimidazole, Anti-inflammatory, Analgesic, Antiviral, Anticancer, Tuberculosis activity.