Abstract

DEVELOPMENT AND EVALUATION OF A NANOLIPOSOMAL HERBAL PATCH CONTAINING TURMERIC, GINGER, AND HATHJOD EXTRACTS FOR TOPICAL PAIN RELIEF AND ANTIINFLAMMATORY APPLICATION

Mrs. Megha Shah*, Avinash Goudgave, Omkar Karbhal, Neha Wable and Shruti Gaikwad

Abstract

Background: Managing pain and inflammation is a daily challenge, often addressed with oral and topical analgesics. While medications like NSAIDs and opioids are effective, they come with significant side effects, including stomach irritation, cardiovascular risks, and dependency concerns. Herbal alternatives such as turmeric (Curcuma longa), ginger (Zingiber officinale), and hathjod (Cissus quadrangularis) have long been recognized for their pain-relieving and anti-inflammatory properties. However, their poor bioavailability and instability limit their full therapeutic potential. Objective: This study focuses on developing a nanoliposomal herbal patch designed to enhance the delivery of these natural extracts, ensuring better absorption, prolonged release, and effective topical pain relief. Methods: We used the thin-film hydration method to encapsulate the herbal extracts in nanoliposomal, which were then incorporated into a transdermal patch via the solvent evaporation technique. The patch was evaluated for physicochemical properties, in vitro drug release, and biological efficacy. A Franz diffusion cell was used to monitor drug release over time, and both in vitro and in vivo studies assessed its pain-relieving and anti-inflammatory potential. Result: The nanoliposomal herbal patch demonstrated improved stability, deeper skin penetration, and controlled drug release for up to 24 hours. Animal studies using the carrageenan-induced paw edema model showed a 72% reduction in pain and a 68% decrease in inflammation, making it comparable to conventional pharmaceutical treatments. Conclusion : These findings suggest that the nano liposoma l herbal patch is a powerful and natural alternative for managing pain and inflammation. Its enhanced bioavailability and sustained therapeutic effects make it a strong candidate for further clinical research and commercial development in herbal medicine.

Keywords: Nano liposomes, transdermal drug delivery, herbal medicine, turmeric, ginger, Cissus quadrangularis , pain relief, inflammation therapy