Abstract

ANATOMICAL, PHYTOCHEMICAL AND In vitro ANTI-ARTHRITIC SCREENING FROM WHITE FLOWERS OF Hibiscus rosa-sinensis L. GEL.

G. Shanthini Nachiar*, R. R. Harini, K. Nithyakalyani, S. Kokila, S. Madhavan, B. Nithyashree and M. Rajalakshmi

Abstract

Arthritis, a chronic inflammatory disorder affecting joints. It impacts among the individuals of various age groups. The quest for effective remedies against arthritis has led to the exploration of natural compounds with therapeutic potential. White hibiscus (Hibiscus rosasinensis L.), a flowering plant rich in bioactive constituents, has gained attention for its purported anti-inflammatory properties. This study aims to evaluate the efficacy of an Anti-Arthritic gel formulated from the ethanolic extract of white flowers of Hibiscus rosa-sinensis. White hibiscus flowers are renowned for its diverse pharmacological activities, including anti-inflammatory, analgesic, and antioxidant properties, attributed with constituents such as flavonoids, phenolic compounds, and polysaccharides. Previous research suggests that these bioactive compounds may alleviate arthritis symptoms by modulating inflammatory mediators and reducing oxidative stress. The formulation of Anti-Arthritic gel offers a promising approach for localized delivery of bioactive compounds, potentially enhancing therapeutic efficacy while minimizing systemic side effects. Moreover, topical administration facilitates direct targeting of inflamed joints, providing rapid relief from pain and inflammation associated with arthritis. The findings of this study hold significant implications for the development of novel therapeutic strategies for arthritis management. If proven effective, the Anti-Arthritic gel derived from white Hibiscus flower extract could emerge as a safe and affordable alternative to conventional treatments, offering hope for individuals suffering from arthritis induced discomfort and disability.

Keywords: Hibiscus rosa sinensis W hite F lower s , Bovine serum, Gallic acid, Carbopol 94