Abstract

FORMULATION AND EVALUATION OF HERBAL NANOGEL USING SESBANIA GRANDIFLORA LEAVES EXTRACT

S. Iyswarya*, Dr. S. Mohamed Halith and A. Meena

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Abstract

Interest in usage of herbal remedies have significantly increased in recent years, even in areas where access to modern treatment is available. Phytochemicals and herbal remedies have gained popularity recently a lot of attention because medicinal plants are the primary source of bioactive molecules utilized in both conventional and medicine of the modern age. The present research has been undertaken with the aim to formulate and evaluate the herbal Nanogel containing Sesbania grandiflora leaves extract. Firstly, the preparation of Nanoparticle was carried out by using chitosan polymer. Nanogel formulation was designed by using ethyl acetate extract in varied concentrations and was evaluated using physiological measurements. The maceration procedure was used to prepare the ethanolic extracts. In next step involved stirring continuously as you thoroughly combined each ingredient with the Carbopol 940 Nanogel was prepared. The Nanogel was prepared by using Carbopol 940, Sodium CMC, Sesbania grandiflora extract, Chitosan Nanoparticle, Glycerin, Methyl paraben, Propyl paraben and required amount of distilled water. Then skin pH (6.8-7) was maintained by drop wise addition of tri-ethanolamine. The physiochemical parameters of formulations (pH, viscosity, spreadability etc.) were determined. The results showed that formulation F3 was one of the best formulations among the all-other formulations.

Keywords: Herbal Nanogel, Sesbania grandiflora , Anti inflammatory activity