Abstract

DEVELOPMENT AND CHARACTERIZATION OF POLY-HERBAL ANTACID FLOATING TABLETS

Khushboo Vaghela*, Divya Mahyavanshi, Vidhi Jethva, Ankit Modi, Mansi Kaushal and Divyakant Patel

Abstract

One of the most prevalent gastrointestinal (GI) issues of our time, gastric ulcers (GUs) are open sores that form on the inside of the stomach's mucosal lining and affect about 10% of the global population. Due to the breakdown of the equilibrium between the gastric mucosa's natural defence mechanism, aggressive factors (such as the secretion of gastric acid and pepsin, oxidants, and free radicals,), and exogenous factors (such as Helicobacter pylori infection, alcohol use, and non-steroidal anti-inflammatory drugs), the disorder is multifactorial and complex. In the modern era, H2 antihistamines, proto-pump inhibitors, ulcer protectants, and antiulcer medications are used to treat and prevent GUs. Extended usage of these chemicals is frequently linked to problems such as diarrhoea, anaemia, and enterochromaffin-like (ECL) cell hyperplasia. Herbal remedies have been used since ancient times to treat a variety of disorders like gastroprotective and anti-ulcer activities. For the treatment of anti-ulcer activity Poly-herbs are used for treatment like Triphala powder(Amla, Harde, Baheda), pumpkin seed powder, black cumin seeds powder, fennel fruit powder, black raisin powder, fenugreek seeds powder all having the gastro-intestinal protective action and also soothes the mucosal lining of the stomach. Floating tablets is prepared by the direct compression method to increase the residence time of drug in the stomach. Aqueous extract is prepared by Maceration technique and excipients sodium bicarbonate, HPMC K4H, sodium CMC, citric acid is added and mixed properly with mortar and pestle. Evaluation is performed like pre-compression evaluation, post-compression evaluation, floating lag time and total floating time is evaluated.

Keywords: Antacid, H.pylori, floating tablets, Cucurbita maxima, Terminalia bellerica, Emblica officinalis, Terminalia chebula, Nigella sativa, Trigonella foenum graceum, Vitis vinifera, Foeniculum vulgare Miller.