Abstract

COMPHREHENSIVE REVIEW ON LIPOSOME DRUG DELIVERY SYSTEM

Sravani V., Moulika P.*, Nithisha Ch, Sahithya R., Nagini T. and Bhargavi V.

Abstract

Liposomes are spherical vesicles composed of one or more concentric phospholipid bilayers that surround an aqueous core. An amazing method of delivering medication are benign and biodegradable liposomes. While reducing systemic toxicity, they have enhanced therapeutic treatment efficacy by stabilizing molecules, breaking down cellular and tissue absorption barriers, and boosting drug biodistribution to target sites in vivo. Emphasizing their fundamental principles, this review gives a general picture of liposomes. First addressed were the essential design elements of a suitable liposomal formulation; then, liposome manufacture and drug loading techniques came second. Before use, liposomes must be completely examined to guarantee in vitro and in vivo performance. Several properties— including size, polydispersity index, zeta potential, shape, lamellarity, phase behavior, encapsulation efficiency, and in vitro drug release— used to define liposomes were investigated. Along with liposome stability and constraints, the topic covered liposome functionalization and successful targeting strategies. At last, the goal of this work is to investigate the present market for liposomes as a method of drug delivery in several therapeutic uses.

Keywords: Liposomes, Spherical vesicles, Phospholipid bilayers, Biodegradable.