Abstract

STUDIES ON SYNTHESIS, ANTIMICROBIAL ACTIVITY AND INSILICO ANALYSIS OF SUBSTITUTED PYRIMIDINES

Narendra B. Gowda*, Rachana M. L. and Nisarga Prakash M.

Abstract

A series of substituted pyrimidines were synthesized from corresponding chalcones. The chalcones were prepared via Claisen Schimdt condensation between p-chloroacetophenone and substituted benzaldehyde. These chalcones were then cyclised with guanidine nitrate via Michael’s addition to obtain substituted pyrimidines. Subsequently, the pyrimidines were acetylated to yield substituted pyrimidine derivatives. All pyrimidine derivatives were characterized by IR, NMR spectral studies. Their in-vitro antimicrobial activity was evaluated using the cup-plate method. In silico target studies were conducted using PyRx and other computational tools. The compound 3a,3b,3f,3g exhibited significant activity compared to the standard drug ciprofloxacin.

Keywords: Chalcone, Pyrimidine, Antimicrobial activity, Molecular docking.