Abstract

FORMULATION AND EVALUATION OF HERBAL TRANSDERMAL PATCH FOR TREATMENT OF VARICOSE VEIN

Prerna Dhiwar and Suchita Wamankar*

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Abstract

With controlled medication release, enhanced patient compliance, and fewer systemic side effects, transdermal drug delivery devices present a viable substitute for traditional drug administration. The medicinal plant Gotu kola (Centella asiatica) is well-known for its antiinflammatory, wound-healing and neuroprotective qualities. The purpose of this study is to develop and assess a transdermal patch that contains Gotu Kola extract in order to investigate its potential for longterm medication release and therapeutic effectiveness. To maximize drug release and skin permeability, the patches were made utilizing a solvent casting technique using several polymeric combinations, plasticizers, and penetration enhancers. Thickness, moisture content, folding endurance were among the physicochemical parameters that were assessed for the formulations. A promising option for transdermal medicinal applications, the improved formulation demonstrated favorable mechanical features, extended drug release, and efficient skin penetration. To confirm the effectiveness and safety of the developed transdermal patch, more in-vivo research and clinical trials are needed.

Keywords: Gotu Kola, Centella asiatica, Transdermal patch, Drug delivery, Formulation, Evaluation, Neuroprotective, Wound healing.