Abstract

AN OVERVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW

Aditya Dagade*, Ganesh More, Ashish Kadam, Kunal Jagtap and Rahul Shinde

Abstract

The development of oral controlled release and site-specific drug delivery systems has attracted considerable attention in the pharmaceutical industry to provide enhanced therapeutic benefits. The process of drug absorption within the gastrointestinal tract is highly unpredictable, and extending the gastric retention time of the dosage form increases the duration for drug absorption. A gastro retentive drug delivery system represents one of the innovative strategies aimed at prolonging the time a drug remains in the stomach, thus facilitating targeted drug release for both local and systemic effects. This strategy is particularly advantageous for medications that have a limited absorption window in the upper portion of the gastrointestinal tract. Various methods for gastro retentive drug delivery systems, including both floating and non-floating approaches, are explored in this review. Additionally, this review outlines the advantages, disadvantages, and evaluation criteria associated with gastro retentive systems.

Keywords: Gastro retentive drug delivery system, non-floating system, floating system, evaluation parameters.