Abstract

EUTECTIC MIXTURES IN DRUG DELIVERY: INNOVATIONS AND CHALLENGES

Srushti S. Gode*, Neha S. Ghosalkar, Rini Punathil and Sanket Dharashivkar

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Abstract

Eutectic the new wave in pharmaceutical formulations to solubilize and improve bioavailability of poorly water-soluble drugs. Eutectic systems contain two or more components, and when combined, they have a melting point that is lower than those of their individual compounds, thereby increasing solubility or dissolution rate of active pharmaceutical ingredients. This review showcases the promise of eutectic mixtures to meet formulation hurdles of low solubility and bioavailability. Mechanisms of eutectic formation, preparation methods, and thereby influence on drug-releasing characteristics are discussed. Eutectic mixtures as associated with various formulation approaches would be examined-into solid dispersions, co-crystals, and into amorphous systems-delineating improvement to drug absorption. Case studies are presented in the review for those successful eutectic mixtures in formulation for use prior to clinical. The work also examines other essential hurdles such as stability, scalability, and regulatory hurdles that can be harnessed towards optimizing formulation strategies for maximized therapy. In summary, therefore, eutectic mixtures are not only very versatile but also very potent in terms of enhancing not only solubility but bioavailability in the design of more efficient pharmaceutical formulations.

Keywords: Eutectic mixtures, solubility enhancement, bioavailability, solid dispersions, co-crystals, amorphous systems.