Abstract

MICROBIAL MEDIATORS OF THE GUT-BRAIN AXIS: IMPLICATIONS FOR NEUROLOGICAL AND PSYCHIATRIC DISORDER

Pranali P. Zodage*, Dakshata V. Golhe, Madhuri V. Supekar, Chaitali S. Jadhav

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Abstract

The human gut microbiome comprise a huge number of microorganisms with coevolutionary associations with humans. It has been repeatedly revealed that bidirectional communication exists between the brain and the gut and involves neural, hormonal, and immunological pathways. Evidences from neuroscience researches over the past few years suggest that microbiota is essential for the development and maturation of brain systems that are associated to stress responses. This review summarizes recent data on the role of microbiota- gut-brain axis in the pathophysiology of neuropsychiatric and neurological disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson‟s disease, migraine, and epilepsy.

Keywords: Microbiota Gut-Brain Axis, Gut Microbiota, Probiotics, Enteric Microbiota.