Abstract

A REVIEW ON NANOEMULGELS: IN PHARMACEUTICALS AND COSMETICS

Bharath B. H.*, Lakshmi Radhika G.. Bhavana S. N., Hemanth S. N., Venkanagouda Shridharagouda Agasumundin

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Abstract

Skin, the largest organ in the human body, plays vital roles in protection, sensory functions, temperature regulation, and more. Topical drug delivery, particularly through nanoemulgel formulations, offers targeted drug delivery with advantages such as reduced systemic toxicity, enhanced patient compliance, and improved drug absorption. Nanoemulgel combines nano emulsion with hydrogel systems to enhance skin penetration, incorporating lipophilic drugs while improving drug viscosity. Nano emulsions Preparation methods include high-energy and low-energy emulsification. Nanoemulgel preparation involves incorporating the Nano emulsion into a gel base to improve drug loading, release control, and skin permeation. Characterization studies for nanoemulgel formulations include zeta potential, rheology, droplet size and polydispersity index (PDI), spreadability testing, in-vitro release testing (IVRT), and bio-adhesive properties, ensuring stability, effective drug release and skin adhesion.

Keywords: Skin, Topical drug delivery, Nanoemulgel, Nano emulsion.