Abstract

ONE-POT SYNTHESIS OF BENZOXAZOLE ANALOGOUS CATALYZED Zn (OAc)2

S. Harsha Vardhan, G. Yashwanthi Sai, B. Ishwarya Lxami and N. Krishnarao*

Abstract

In this study, we present the design, synthesis, structural characterization, and biological evaluation of new benzoxazole from 2- aminophenol and substituted aldehydes in the presence of catalytic quantity of Zn (OAc)2 at room temperature. as possible therapeutic agents a two-component, one-pot cyclocondensation reaction using conventionally produced methods. Using mass spectrometry, 1HNMR, and 13CNMR, all substances were described. Furthermore, the desired compound outperformed the standard antibacterial activity by exhibiting notable against important bacterial strains, streptomycin and certain of its derivatives demonstrated moderate to high antibacterial effectiveness. These findings show that benzoxazole derivatives hold substantial promise for further development as medicinal agents.

Keywords: Benzoxazole, One-pot two-component synthesis, 2- Aminophenol, Substituted aromatic aldehydes, Zn (OAc) 2, antibacterial activity