Abstract

REACTIVATION EFFICACY OF SARIN-INHIBITED ACETYLCHOLINESTERASE BY OBIDOXIME CHLORIDE IN THE PRESENCE OF SELECTED EXCIPIENT AND SEPTUM MATERIALS AT DIFFERENT TEMPERATURE

Radha Sharma*, Suman Jain and Dr. R.Vijayaraghavan

Abstract

Objective The aim of this study is to propose in-vitro AChE reactivation study as a tool to check the compatibility of combinations of obidoxime chloride with different formulation excipients. Materials and methods Obidoxime chloride is highly water soluble drug. In this study, with the help of different types of preservatives, stabilizers and packaging materials different types of formulation combinations were developed to overcome the problem of instability. Developed different combinations of obidoxime chloride for the immediate shelfadministration were subjected for in-vitro reactivation against the inhibition of acetylcholinesterase (AChE) activities induced by sarin. Results In-vitro reactivation studies suggest that compatibility of obidoxime chloride in autoinjector cartridge is good with bromobutyl back septum.

Keywords: obidoxime, acetylcholinesterase, autoinjector and bromobutyl.