Abstract

HARNESSING IMIDAZOLE CHEMISTRY IN THE FIGHT AGAINST CANCER: INSIGHTS AND ADVANCES

Yogesh Gupta*, Nitiraj Pawar, Ganesh Lobhe, Sumit Kumbhar, Onkar Jadhav and Sakib Shikalgar

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Abstract

Imidazole is a five-membered ring containing three carbon atoms and two nitrogen atoms. It is found in many important biological molecules like purines, histamine, and nucleic acids. Imidazole derivatives are significant in medicinal chemistry, especially for cancer treatment. This review focuses on research from 2018 to 2020, highlighting the anticancer properties of imidazole and fused imidazole compounds. Cancer is a major global health challenge, and while advances in targeted therapies have been made, resistance to these treatments is common. One promising compound, compound has shown the ability to kill breast cancer cells while sparing healthy cells, making it a potential aromatase inhibitor. The review discusses how various imidazole derivatives work against cancer by affecting key cellular targets, including microtubules and specific enzymes. Some compounds act through mechanisms that are still not fully understood. Additionally, the review looks at how changes in the structure of these compounds can impact their effectiveness. Overall, this overview aims to highlight recent findings and inspire further research into imidazole-based drugs for cancer treatment, emphasizing their potential to provide new therapeutic options.

Keywords: Imidazole, Anticancer, Tumour, Biological Activity, Kinase inhibitor.