Abstract

STUDY AND ANALYZING THE HEPATIC ACTIVITY OF SOME ENDEMIC PLANTS PRODUCING HEPATOPROTECTIVE ACTIVITY

T. Afreen*, P. Vasanth Kumar, Syed Mohammed Shafiulla, B. Amrutha, P. Pavani, P. Likhitha, P. Lahari, K. R. Deeskhitha, G. Devi Priya and D. Ashika

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Abstract

Liver being an important organ is often exposed to array of threats. Injury to the liver can lead to deterioration of its functions and may culminate in organ failure. Te likely risk factors for the development of the liver diseases have been suggested to include pathogenic microorganisms and viruses, hepatotoxins, overdose and duration of drugs, obesity and malnutrition, alcohol, autoimmune disorders, type-2 diabetes, and genetic factors. Te diseases of the liver are of public health concern because orthodox remedies for liver diseases produce limited results with attendant side efects. As such, utilization of complementary and alternative herbal medicine has attracted research interest for novel plausible hepatoprotective agents capable of ameliorating or reversing liver injury with little side efects]. Over the years, this search has gained impetus with many studies focusing on hepatoprotective potentials of plant drugs. Carbon tetrachloride (CCl4) is a known hepatotoxicant in humans and animal models. It has been successfully used in hepatotoxicity research as a model and to appraise hepatoprotective agents. With reports on the rise of liver diseases and numerous literature reports on plants with potential hepatoprotective activity, this review highlighted the mechanism of CCl4 toxicity, the signifcance, efectiveness, and underlying mechanisms of herbal plant extracts on CCl4-induced toxicity in experimental animal models.

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