Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF PLICOSEPALUS ACACIA EXTRACT CAPSULES DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR HEPATOPROTECTIVE

Dr. Mahmoud Mahyoob Alburyhi* and Dr. Amina El-Shaibany

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Abstract

The Plicosepalus Acacia is plant widely distributed in Yemen, a large number of medicinal plants have been tested and found to contain active principles with curative properties against a variety of diseases. Liver protective plants contain a variety of chemical constituents like flavonoids, Phenol, Tannins, Steroids, Amino acid and Triterpene glycoside. Therefore, a large number of plants and formulations have been claimed to have hepatoprotective activity so the development of plant based hepatoprotective drugs has been given importance in the global market. Plicosepalus Acacia is commonly used in traditional medicine for a wide range of ailments including hepatoprotective activity. A Plicosepalus Acacia was formulated as capsules and evaluated for organoleptic properties and other evaluation parameters. It was concluded that the formulation of Plicosepalus Acacia extract medicinal herbs capsules delivery system as anadvanced phytotherapy approach for hepatoprotective according to the best results of in-vitro dissolution was found to be 76.8% within 45 minutes in acid medium and were evaluated.

Keywords: Plicosepalus Acacia, Extract, Capsules, Medicinal herbs, Hepatoprotective activity, Phytotherapy.