Abstract

AN EFFICIENT SYNTHESIS OF N-SUBSTITUTED ACRIDIONE DERIVATIVES AND EXPLORED BIOEVLUATION

K. Priyank, A. Kumar Venkata Sai, B. Siva and K. Jagannadham*

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Abstract

The present versatile and an efficient synthesis of N-alkyl derivatives of acridine 10-benzyl-9-(3,4-dimethoxyphenyl)-3,3,6,6-tetramethyl- 3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione is by obtained from 9-(4-bromophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10- hexahydroacridine-1,8(2H,5H)-dione with substituted (bromomethyl)benzene which is also three component cyclocondensation of 1,2-dicarbonyl compounds like dimedone, bromo benzaldehyde and ammonium chloride in the presence CAN and ethanol as solvent condition. All the compounds were evaluated by advanced spectroscopic data (1H NMR, 13C NMR& LCMS) and the structural determination of the novel derivations was calculated by elemental analysis. In the present study, ten hybridized imidazoles derivatives were synthesized via cyclo condensation and evaluated for their invitro antimicrobial activity.

Keywords: Dimedone, Chlorobenzalehyde, CAN, 10-benzyl-9-(3,4-dimethoxyphenyl)- 3,3,6,6-tetramethyl-3,4,6,7,9,10-‘hexahydroacridine-1,8(2H,5H)-dione,9-(4-bromophenyl)- 3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione, Anti-bacterial activities.