Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE 20 MG. TENELIGLIPTIN TABLETS

Vinod D. Usnale*, Krishna Shivajirao Patil, Swapnil S. Palapure, Ritesh R. Patil, Nila

Abstract

Teneligliptin 20 mg. immediate release tablets were developed by using single station compression machine and evaluated as part of this study utilizing a wet granulation technique and various ratios of superdisintegrates and binder. It falls under Biopharmaceutical Classification System Class II. The results of the early pre-formulation experiments were found to be within the limits. All of the four mentioned Trial batches were made, and the granules' pre-compression characteristics such as loss on drying, bulk density, tapped density, and compressibility index were assessed. Tablets' weight fluctuation, thickness, hardness, and friability were also assessed; the assay and disintegration time were found to be within acceptable ranges. in this study two disintegrants ie. crosscarmellose sodium and sodium starch glycolate were used and which shows better improvement in disintegration of prepared tablets. The formulation F4 revealed a 91.7% drug release within 60 minutes, according to dissolving studies,which were use to make the final formulation choice.

Keywords: Teneligliptin, Immediate Release Tablets, disintegration, super-disintegrants.