Abstract

SYNERGISTIC COMBINATION OF QUERCETIN AND 4- HYDROXYISOLEUCINE: A NATURAL STRATEGY FOR MANAGING DIABETES

Audumbar Manohar Waghmode*, Kajal Bhagvan Kamble, Akram Sardar Dange, Nupura Ramesh Sakale and Suyog Kiran Harugade

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Abstract

Fenugreek, a medicinal plant, has demonstrated notable anti-diabetic properties, including the ability to lower fasting blood sugar and enhance glucose tolerance. A systematic review evaluating its hypoglycaemic effects reported significant reductions in fasting blood glucose, postprandial glucose levels, and HbA1c following fenugreek intake. Nonetheless, variability in study quality and consistency remains a limitation. Additionally, the study explored the antidiabetic efficacy of polyphenol extracts derived from guava pulp, seeds, and leaves through in vivo experiments on albino rats. Supplementation with these polyphenols led to increased feed intake and body weight, along with decreased levels of cholesterol, HDL, blood glucose, and triglycerides. The extracts also inhibited α-amylase activity and glucose absorption. These results support the potential use of guava pulp polyphenol extracts at a dosage of 200–250 mg/kg body weight as a natural alternative to conventional antidiabetic medications.

Keywords: Trigonella foenum-graecum L. and Psidium guajava L., Combined Therapeutic Effects, Polyherbal Interactions, Diabetes Control, Regulation of Blood Sugar Levels.