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Abstract

ANALYTICAL METHOD FOR THE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DOMPERIDONE BY H.P.L.C.

Sheeraz Ahmad Wagay*, S.S.Ajay, Sudhanshu Dhar Dwivedi and Suryakant Barkhe

Abstract

Chromatography has grown to be the premiere method for separating closely related chemical species. It is employed for the qualitative identification and quantitative determination of separated species. Chromatography owes its precipitous growth during the past four decades in part to its speed, simplicity, relatively low cost and wide applicability as a separating tool. For planar chromatography the area covered by the separated species serves as the analytical parameter. Since the conditions are properly controlled, these parameters vary linearly with concentration. The estimation of two different drug components - Paracetamol and Domperidone present in a single formulation is done using acetate buffer along with Methanol in the proportion of 35: 65. The separation is done on a C18 column and it is estimated at a λ max of 280 nm. The detection limits range from a 0.7 to 1.5 mg/ml for Paracetamol and 0.014 to 0.030 mg/ml for Domperidone. The specificity for interference of any peak with main peak of interest is checked. The individual drug is scanned for assuring the λ max. The system suitability by precision is also checked to ensure the analytical method.

Keywords: High Performance Liquid Chromatography, Reverse Phase, Paracetamol and Domperidone oral dosage form.


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