Abstract

ROSACEA: A COMPREHENSIVE REVIEW OF PATHOPHYSIOLOGY, DIAGNOSIS, AND MANAGEMENT

Omkar Ananda Chavan*, Audumbar Manohar Waghmode and Prajakta Sardar Mane

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Abstract

Rosacea is a prevalent inflammatory dermatological illness that primarily affects the central area of the face and is chronic and prone to relapse. It can manifest as a variety of clinical symptoms, including telangiectasia, papules, pustules, ocular signs, and temporary or chronic face erythema. Although the precise pathophysiology is still complex and poorly understood, deregulation of the innate and adaptive immune systems, neurovascular instability, changes in the skin microbiota (particularly Demodex mites), and hereditary susceptibility are all contributory factors. Additionally, recent research highlights the connection between rosacea and systemic conditions such gastrointestinal dysfunction and cardiovascular disease. The majority of the diagnostic evaluation is clinical, with non-invasive imaging methods and occasionally histological evaluation as supplements. Topical and systemic medicines, laser therapy, and lifestyle changes are some examples of management techniques.[1–5]

Keywords: Rosacea, Pathophysiology, Demodex, Inflammation, Treatment, Topical Therapy, Systemic Therapy.