Abstract

ANTIALLERGIC, ANTIANAPHYLACTIC & MAST CELL STABILIZING POTENTIAL OF VITIS VINIFERA IN MANAGEMENT OF ASTHMA

Suralkar A A*, Kharade R G and Bora V R

Abstract

The anti-allergic, anti-anaphylactic and mast cell stabilizing activity of ethanolic extract of Vitis vinifera (VV) was evaluated pharmacologically by using milk induced leukocytosis and eosinophilia in mice, compound 48/80 induced mast cell degranulation and egg albumin induced passive paw anaphylaxis in rats. In the milk induced eosinophilia and leukocytosis, VV showed an significant decrease in the no. of eosinophils and leukocyte count in mice; in the compound 48/80 induced mast cell degranulation VV showed significant protection of mast cells in rats, and in the egg albumin induced passive paw anaphylaxis, VV showed significant reduction in the paw edema volume. These results suggest that VV may prove to be a potential therapeutic agent in management of asthma which may be due to anti-stress, mast cell stabilizing and anti-inflammatory activity.

Keywords: compound 48/80, milk, egg albumin, anaphylaxis.