Abstract

CASE REPORT ON CARBAMAZEPINE INDUCED STEVENS JOHNSON SYNDROME-TOXIC EPIDERMAL NECROLYSIS OVERLAP: A SEVERE CUTANEOUS ADVERSE DRUG REACTION

*Sneha Lissue Antony and Anna B. Varghese

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Abstract

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare yet serious adverse mucocutaneous reactions, presented with epidermal necrosis and detachment frequently induced by medications like carbamazepine. SJS-TEN overlap denotes a clinical presentation characterized by the severity of a skin condition that lies between Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), involving 10-30% of the body surface area with epidermal detachment. Here we report the case of a 59 year old female who developed SJS-TEN overlap following the initiation of carbamazepine therapy and managed with systemic corticosteroids. This case emphasizes the importance of pharmacovigilance, genetic screening and early intervention in managing potentially life threatening cutaneous adverse drug reactions.

Keywords: Stevens Johnson Syndrome, Toxic Epidermal Necrolysis, Carbamazepine, Pharmacovigilance, Mucocutaneous reaction.