Abstract

HUMAN PROBIOTIC GLYCOCONJUGATES RECOGNIZING SYSTEMS AGAINST DISEASES OF MICROBIOCENOSES IN HUMAN ORGANISM

Lakhtin V. M.*, Lakhtin M. V. and Aleshkin V. A.

Abstract

The representations of diseases of biotope microbiocenoses are given and developed using the example of mucosal biotopes of open cavities of the human body. Various aspects including ways and factors influencing the prevention and treatment of such diseases are considered. Potential of influence of human probiotic glycoconjugates recognizing systems (HPGRS) with respect of infective process, prevention of diseases of human organism biotope microbiocenoses and reduction of their severity is systemized. HPGRS represent new class of natural bioeffectors functioning in biocontrol of biotope status. They counteract conditionally pathogenic microorganisms and acting pathogens at the level of niche organization of biotope microbiocenoses. They are characterized by (Genus, species or strain(s))-directed antimicrobial action. HPGRS, probiotic and leader microorganisms of protection significance decrease infective risk in biotope microbial societies. These indicated factors can increase final effectiveness of antiinfection preparations and procedures usually used in treatments. Combinative application of HPGRS and other important agents in organism biotopes is perspective for prophylaxis and therapy of microbiocenose of states before (Importance for early effective antimicrobial action), during (When direct and indirect possible therapeutic effects take place) and after (In prolongation of convalescence achieved) the human diseases. Among applications the combination of the synergy of HPGRS and antibiotics is look like as the most perspective in prophylaxis and therapy of the human biotope microbiocenosis diseases.

Keywords: Probiotics; Lectins; Glycoconjugates; Microbiocenoses; Mucosal biotopes; diseases; Human.