Abstract

PHARMACEUTICAL STANDARDIZATION OF DASHANGA GULIKA

Dr. Manisha Vishwakarma*, Dr. Dilip Prajapati, Prof. B.J. Patgiri

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Abstract

Background: Dashanga Gulika (DG) mentioned by Acharya kashyapa in Kita Visha chikitsa is widely used formulation. Standardization and validation of Ayurvedic polyherbal formulations using modern analytical techniques are crucial to ensure their safety, efficacy, and quality. Dashanga Gulika, a well-known multi-component formulation with diverse therapeutic applications, lacks updated scientific validation to precisely confirm its safety and efficacy. Therefore, an effort was made to standardize the pharmaceutical process of Dashanga Gulika and validate its analytical profile. The objective was to establish a Standard Manufacturing Procedure (SMP) for Dashanga Gulika and to verify its quality control parameters. Methods: Three batches of Dashanga Gulika were prepared in the pharmaceutical laboratory, Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar, following a classical reference. They were further subjected to an organoleptic, relevant physicochemical analysis. Results: A batch of 100g of DG prepared by taking 10g of each ingredient. Approximately 136 ml of water required for levigation of 100gm of powder with yield of 510 Vati of average weight 235.6mg after drying in oven for 1hr at 600C. Resultant product was brown in colour with pungent and bitter taste. In all the batches weight variation of tablet was in normal range (+7.5%). pH, LOD, water soluble extract, alcohol soluble extract didn’t show great variation. Conclusion: This report serves as an initial step in generating results for the standardization and validation of DG, which can be utilized as a reference for future studies. Additionally, further research is needed to investigate and confirm the therapeutic potential of this formulation.

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