Abstract

THE ROLE OF NEUROINFLAMMATION IN THE PROGRESSIVE OF ALZHEIMER'S DISEASES

Devendra Kumar*, Vaishnavi Tripathi, Ansuman Verma, Garima Awasthi, Moni Rawat

Abstract

The idea that neuroinflammation is linked to the pathophysiology of Alzheimer's disease (AD) has been bolstered by a substantial body of information gathered over the last ten years. The classic and alternative pathways of the complement system, pentraxin acute-phase proteins, brain cells including microglia and astrocytes, and other inflammatory elements linked to AD neuroinflammation Peroxisomal proliferatorsactivated receptors (PPARs), nicotinic acetylcholine receptors (AChRs) of the neuronal type, and cytokines and chemokines. One of the primary pathologic characteristics of AD is beta-amyloid protein (A), which is produced by both astrocytes and microglia. It has been demonstrated that A itself functions as a pro-inflammatory agent, activating a number of inflammatory components. Studies have provided more evidence that neuroinflammation plays a part in AD.

Keywords: Alzheimer’s diseases, Pentraxins, Cytokines, Prostaglandin, Microglia, Astrocytes, NSAIDs, Glucocorticoid steroid, Neurones.