Abstract

EVALUATION OF RADICAL SCAVENGING, CYTOTOXIC EFFECT AND ANTIBACTERIAL ACTIVITY OF BIOLOGICALLY SYNTHESIZED SILVER NANOPARTICLES USING PITTOSPORUM F.DRYAND

S.Gopalakrishnan, S. Yamini Sudha Lakshmi* and P.Arumugam

Abstract

Crystalline Silver Nano particles have found numerous applications in the medicinal field include diagnostic applications and therapeutic applications. In this study, the silver nanoparticles was synthesized biologically using Pittosporum Dryand leaf extract as reducing agent and evaluation of radical scavenging and toxicity effect and antimicrobial action were carried out. The formation of silver nanoparticles was indicated by the colour change from colourless to reddish brown and the particles were characterized by UV-vis, FTIR, ERD, SEM, and TEM analysis. These nanoparticles were found to have sufficient antimicrobial activity, signified radical scavenging capacity. These nano particles showed potent cytotoxic activity against MCF7 liver cell line also found that increase in concentration of the sample, the viability of MCF7 cells decreased. Hence silver nanoparticles synthesized from Pittosporum Dryand possess potential applications in medicine and pharmaceutical fields.

Keywords: Biosynthesis, FTIR, XRD, TEM, Radical scavenger, Pittosporum f.Dryand.