Abstract

FORMULATION AND EVALUATION OF PHYLLANTHUS EMBLICA GEL FOR MANAGEMENT OF MOUTH ULCERS

M. J. Patil* M. Pharm, Ph.D., V. S. Shirsat, A. M. Nar, Prabhakar Santosh Humbe, Saniya Santosh Dichvalkar, Tejas Ramesh Humbe, Supriya Uttam Chavan and Rohan Rajaram Bhovad

Abstract

Native to India and Southeast Asia, Phyllanthus emblica L., also referred to as amla, is a tree valued for its powerful biological properties and abundant phytochemistry. Although amla fruit has been extensively researched, more recent studies have concentrated on the possible anti-aging effects of amla branches. Standardized for phenolic acids like ferulic and sinapic acids, amla branch extract showed strong anti-tyrosinase, anti-melanogenesis, antioxidant, and matrix metalloproteinase-2 inhibitory properties. Effective cellular activity, melanin suppression, and skin protection properties were demonstrated by the extract at 0.1 mg/mL. In a single closed patch test, a topical gel containing 0.1% of the extract was determined to be stable, safe, and non-irritating. Over the course of 84 days, 20 volunteers in a randomized, double-blind, placebo-controlled clinical investigation showed better elasticity, lighter skin, improve elasticity, hydration, and reduced wrinkles. According to scientific data, polyphenols and vitamin C are essential components of fruits and other parts of the amla tree. In addition to significant in vivo benefits, such as enhanced antioxidant status and activity of the endogenous antioxidant defense system, the rich composition of polyphenol and vitamin C confers significant antioxidant activity. The anticancer, anti-inflammatory, digestive tract, and neurological protecting properties, as well as the anti-hyperlipidemia and antidiabetic properties, are additional possible health advantages. The encouraging findings of research on the bioactive components in amla provide credence to their potential contribution to illness prevention and health promotion.

Keywords: Phyllanthus emblica, phytochemical composition, pharmacological properties, natural product, bioactive substances.