Abstract

POLY CYSTIC OVARIAN SYNDROME AND PERIODONTITIS – CURRENT INSIGHTS

Kasukurthi Komali, Syed Afzal, Suryakanth Malgikar^*, Raja Babu Palaparthy and Juliet Josephine Johnson

Abstract

Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age, characterized by irregular menstrual cycles, hyperandrogenism, and polycystic ovaries. Periodontitis, a chronic inflammatory disease of the gums and supporting structures of the teeth, has been increasingly linked to various systemic conditions, including PCOS. This connection is thought to be mediated by the underlying hormonal and metabolic disturbances associated with PCOS, such as insulin resistance, hyperglycemia, and altered inflammatory pathways. Women with PCOS are at a higher risk of periodontal diseases due to the pro-inflammatory environment and altered immune response seen in this condition. Studies have shown that periodontal disease severity in PCOS patients may be more pronounced compared to women without the condition. Additionally, the presence of periodontitis may exacerbate the metabolic and endocrine dysfunctions of PCOS, leading to a bidirectional relationship between the two. Effective management of both PCOS and periodontitis requires an interdisciplinary approach, emphasizing the importance of early detection, oral hygiene, and metabolic control. This review aims to explore the potential mechanisms linking PCOS and periodontitis, highlighting the need for greater awareness and targeted interventions in managing these interconnected health concerns.

Keywords: Poly cystic ovarian syndrome, Periodontitis, Cytokines, Inflammation.