Abstract

A REVIEW OF TREATING BREAST CANCER BY INSILICO METHOD- NATURAL VS SYNTHETIC DRUGS

Dr. G. Abirami*, Dr. D. Nagavalli, Oviya S., Priyadharshini E., Sharmila B., Sowmiya L., Sumithra S., Vignesh V.

Abstract

Natural compounds are proper tools for inhibiting cancer cell proliferation. Hence, the search for these ligands of over expressed receptors in breast cancer has been a competitive challenge recently and opens new avenues for this drug discovery. In this review we have compared molecular interactions between natural products and synthetic drugs used for breast cancer using molecular docking. We have discussed the classification, signs and symptoms, stages and treatment of breast cancer and in-silico approaches of curcumin and flavonoids used in the treatment of breast cancer. We have concluded that using natural products like flavonoids and curcumin can be better option for the treatment of breast cancer in future as it is more safer to use than synthetic drugs as well as economically. Therefore, curcumin and flavanoids could be used as a anticancer agent for breast cancer.

Keywords: Breast cancer, Curcumin, Flavonoids, Synthetic drugs, Docking.