Abstract

TARGETING DEPRESSION: SYNERGISTIC MODULATION OF P2X7 RECEPTORS BY ALKALOIDS AND POLYPHENOLS

*Vishnupriya B., G. Jasmine Joy Bell, Merlin N. J., Shaiju S. Dharan and Abhiramy S. J.

Abstract

Depression, a complex and debilitating mental health disorder, continues to pose a significant global health burden. Current treatment approaches often exhibit limited efficacy and numerous side effects, necessitating the exploration of novel therapeutic approaches. Alkaloids and polyphenols are naturally occurring compounds found in various plant sources, and have individually demonstrated neuroprotective and mood-stabilizing properties. The P2X7 receptor, a ligand-gated purinergic receptor associated with neuroinflammation and synaptic dysfunction in depression, emerges as a crucial potential target for depression. By combining exploration interactions of alkaloids and polyphenols, this review aims to provide a comprehensive understanding of their combined effects on the P2X7 receptor intricately linked to the pathophysiology of depression. The elucidation of the synergistic effects of these natural compounds on neuroinflammation by modulating the P2X7 receptor opens a new way for the development of innovative therapeutic strategies for depression, with the potential to enhance treatment outcomes and improve the quality of life for individuals affected by this prevalent mental health disorder.

Keywords: Depression, Neuroinflammation, NLRP3 inflammasome, P2X7 receptor, Polyphenols, Alkaloids.